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Article

Genomic and transcriptomic signatures of sequential carcinogenesis from papillary neoplasm to biliary tract cancer.

Journal of hepatology - 1 Jul 2025

Chung Taek, Oh Seungho, Won Jeongsoo, Park Jiho, Yoo Jeong Eun, Hwang Ho Kyoung, Choi Gi Hong, Kang Chang Moo, Han Dai Hoon, Kim Sangwoo, Park Young Nyun

Abstract excerpt

BACKGROUND & AIMS: Papillary neoplasms of the biliary tree, including intraductal papillary neoplasms (IPNs) and intracholecystic papillary neoplasms (ICPNs), are recognized as precancerous lesions. However, the genetic characteristics underlying sequential carcinogenesis remain unclear. METHODS: Whole-exome sequencing was performed on 166 neoplasms (33 intrahepatic IPNs, 44 extrahepatic IPNs, and 89 ICPNs), and...

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Topics

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Share to Bile Duct Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carcinoma, Papillary

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Source

Identifiers

PMID: 39832657
DOI: 10.1016/j.jhep.2025.01.007

Genes

CTNNB1
IMPACT
KRAS
SMAD4

Provenance

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