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Neither alpha-synuclein-preformed fibrils derived from patients with <i>GBA1</i> mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb

2023-08-25

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive motor symptoms and alpha-synuclein (αsyn) aggregation in the nervous system. For unclear reasons, PD patients with certain GBA mutations (GBA-PD) have a more aggressive clinical progression. Two testable hypotheses that can potentially account for this phenomenon are that GBA1 mutations promote αsyn spread or drive the generation...

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Literature Corpus work
98dc4c28-114f-50a5-94d6-14f9a9139585
DOI
10.1101/2023.08.24.554646
Open publication

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Neither alpha-synuclein-preformed fibrils derived from patients with <i>GBA1</i> mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulbDOI 10.1101/2023.08.24.554646
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