Article

PP2A inhibition instructs spliceosome phosphorylation to create splicing vulnerability in colon adenocarcinoma

2023-07-13

Abstract excerpt

<h4>SUMMARY</h4> Protein phosphatase 2A (PP2A) is a versatile enzyme affecting many aspects of cellular physiology. However, it remains unclear which of the cellular processes are most perturbed upon PP2A inhibition and how these perturbations could be exploited therapeutically. We report an unanticipated sensitivity of the splicing machinery to phosphorylation changes in response to PP2A inhibition by LB-100 in...

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Literature Corpus work: 98d3a222-bb45-5a44-a780-69a3bc2ae71c
DOI: 10.1101/2023.07.12.548685

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