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Article

Therapeutic targeting of splicing in cancer.

Nature medicine - 7 Sept 2016

Lee Stanley Chun-Wei, Abdel-Wahab Omar

Abstract excerpt

Recent studies have highlighted that splicing patterns are frequently altered in cancer and that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the splicing of key cancer-associated genes, are enriched in cancer. In parallel, there is also accumulating evidence that several molecular subtypes of cancer are highly dependent on splicing function for cell survival. These findings...

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Share to Spliceosomes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Protein Processing, Post-Translational

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Source

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Identifiers

PMID: 27603132
DOI: 10.1038/nm.4165
PMCID: PMC5644489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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