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Article

The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism.

Cellular oncology (Dordrecht, Netherlands) - 1 Oct 2024

Remmerie Michiel, Dok Rüveyda, Wang Zhigang, Omella Judit Domènech, Alen Sophie, Cokelaere Célie, Lenaerts Lisa, Dreesen Erwin, Nuyts Sandra, Derua Rita, Janssens Veerle

Abstract excerpt

PURPOSE: Uterine serous carcinoma (USC) is generally associated with poor prognosis due to a high recurrence rate and frequent treatment resistance; hence, there is a need for improved therapeutic strategies. Molecular analysis of USC identified several molecular markers, useful to improve current treatments or identify new druggable targets. PPP2R1A, encoding the Aα subunit of the tumor suppressive Ser/Thr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38888850
DOI: 10.1007/s13402-024-00963-5
PMCID: PMC12973965

Genes

PPP2R1A
ATM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The PPP2R1A cancer hotspot mutant p.R183W increases clofarabine resistance in uterine serous carcinoma cells by a gain-of-function mechanism.PMID 38888850Read ↗

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