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Structural Insights into the Catalytic Mechanism of Granzyme B upon Substrate and Inhibitor Binding

2021-01-19

Abstract excerpt

Human granzyme B (hGzmB), which is present in various immune cells, has attracted much attention due to its role in various pathophysiological conditions. The hGzmB activity is triggered at a catalytic triad (His59, Asp103, Ser198), cleaving its specific substrates. To date, the drug design strategy against hGzmB mainly targets the catalytic triad, which causes the non-specificity problem of inhibitors due to the...

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Literature Corpus work
98cbe3f8-c3f0-58a6-8225-5f776a8be49f
DOI
10.22541/au.161104747.79281096/v1
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Structural Insights into the Catalytic Mechanism of Granzyme B upon Substrate and Inhibitor BindingDOI 10.22541/au.161104747.79281096/v1
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