Design and characterization of a novel human Granzyme B inhibitor.

doi:10.1093/protein/gzu052

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Article

Design and characterization of a novel human Granzyme B inhibitor.

Protein engineering, design & selection : PEDS - 1 Jan 2015

Marcet-Palacios Marcelo, Ewen Catherine, Pittman Elliot, Duggan Brenda, Carmine-Simmen Katia, Fahlman Richard P, Bleackley R Chris

Abstract excerpt

The intracellular roles of Granzyme B (GrB) in immune-mediated cell killing have been extensively studied. Recent data also implicate GrB in extracellular pathways of inflammation, cytokine activation and autoimmunity. Targeting (GrB) provides a new pharmaceutical agent for various inflammatory disorders. Serpina3n is a mouse extracellular inhibitor of GrB. There is no apparent equivalent in humans. In this...

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PMID: 25492933
DOI: 10.1093/protein/gzu052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.