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Article

Design of human granzyme B variants resistant to serpin B9.

Proteins - 1 Nov 2012

Losasso Valeria, Schiffer Sonja, Barth Stefan, Carloni Paolo

Abstract excerpt

Human granzyme B (hGB) is a serine protease involved in immune-mediated apoptosis. Its cytotoxicity makes it potentially applicable in cancer therapy. However, the effectiveness of hGB can be hampered by the cytosolic expression of a natural protein inhibitor, human Serpin B9 (hSB9). Here, we used computational approaches to identify hGB mutations that can affect its binding to hSB9 without significantly...

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PMID: 22733450
DOI: 10.1002/prot.24133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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