Article
Human and mouse granzyme M display divergent and species-specific substrate specificities.
The Biochemical journal - 1 Aug 2011
de Poot Stefanie A H, Westgeest Marijn, Hostetter Daniel R, Van Damme Petra, Plasman Kim, Demeyer Kimberly, Broekhuizen Roel, Gevaert Kris, Craik Charles S, Bovenschen Niels
Abstract excerpt
Cytotoxic lymphocyte protease GrM (granzyme M) is a potent inducer of tumour cell death and a key regulator of inflammation. Although hGrM (human GrM) and mGrM (mouse GrM) display extensive sequence homology, the substrate specificity of mGrM remains unknown. In the present study, we show that hGrM and mGrM have diverged during evolution. Positional scanning libraries of tetrapeptide substrates revealed that mGrM...
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