Article

CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation

2026-02-28

Abstract excerpt

Innate immune sensors such as the NLRP3 inflammasome can trigger inflammatory responses within minutes, raising the question of how circadian clocks influence such rapid decisions. Here, we identify a protein-level circadian checkpoint that links core clock components to NLRP3 inflammasome activation. We show that NLRP3 associates with the circadian repressors CRY1 and CRY2, forming oscillatory complexes that rest...

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Identifiers and source

Literature Corpus work: 98b8f36b-01aa-5046-b92b-38d5d1bfa022
DOI: 10.64898/2026.02.26.708242

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