Article
Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.
Gastroenterology - 1 Apr 2018
Pourcet Benoit, Zecchin Mathilde, Ferri Lise, Beauchamp Justine, Sitaula Sadicha, Billon Cyrielle, Delhaye Stéphane, Vanhoutte Jonathan, Mayeuf-Louchart Alicia, Thorel Quentin, Haas Joel T, Eeckhoute Jérome, Dombrowicz David, Duhem Christian, Boulinguiez Alexis, Lancel Steve, Sebti Yasmine, Burris Thomas P, Staels Bart, Duez Hélène M
Abstract excerpt
BACKGROUND & AIMS: The innate immune system responds not only to bacterial signals, but also to non-infectious danger-associated molecular patterns that activate the NLRP3 inflammasome complex after tissue injury. Immune functions vary over the course of the day, but it is not clear whether these changes affect the activity of the NLRP3 inflammasome. We investigated whether the core clock component nuclear...
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