Article

Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells

2020-04-15

Abstract excerpt

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and regenerating muscle using single-nucleus RNA-sequencing (snRNAseq) of isolated nuclei from muscle fibers. This revealed distinct nuclear subtypes unrelated to fiber type diversity, completely novel subtypes as well as the expected ones at the neur...

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Literature Corpus work: 58f5c569-fe3a-5095-bd61-9020ab3c0b2e
DOI: 10.1101/2020.04.14.041665

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