Article

Cell fusion upregulates PD-L1 expression and promotes tumor formation

2022-06-17

Abstract excerpt

MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show that approximately 5% of bladder cancer cells (UMUC-3) fuses with bone marrow-derived MSC (BM-MSC) in co-culture and exhibits increased tumorigenicity. Eleven fusion cell clones are established, and 116 genes are identified whose expression is specifically altered in the fusion cells. Many of...

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Literature Corpus work: 98752a96-8c1a-548f-a091-3e6c36c265d3
DOI: 10.1101/2022.06.14.496068

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