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Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer/STAT3 complex nuclear translocation

2023-12-20

Abstract excerpt

<title>Abstract</title> <p>Background Tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME) and strongly associated with poor prognosis and drug resistance, including immune checkpoint blockade (ICB) in solid tumor patients. However, the mechanism by which TAM affects immune metabolism reprogramming and immune checkpoint signaling pathway in the bladder cancer (BLCA) TM...

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Literature Corpus work
9cd35e19-ae3b-5f61-8f3c-924ecd8006eb
DOI
10.21203/rs.3.rs-3737302/v1
Open publication

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