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Article

Infections in activated PI3K delta syndrome (APDS).

Current opinion in immunology - 1 Oct 2021

Brodsky Nina N, Lucas Carrie L

Abstract excerpt

Activated PI3K-delta Syndrome (APDS), also called PI3K-delta activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency (PASLI), is an autosomal dominant disorder caused by inherited or de novo gain-of-function mutations in one of two genes encoding subunits of the phosphoinositide-3-kinase delta (PI3Kδ) complex. This largely leukocyte-restricted protein complex regulates cell growth,...

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Identifiers

PMID: 34052541
DOI: 10.1016/j.coi.2021.04.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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