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Article

Phenotypic and Immunological Characterization of Patients with Activated PI3Kδ Syndrome 1 Presenting with Autoimmunity.

Journal of clinical immunology - 18 Apr 2024

Li Qifan, Wang Wenjie, Wu Qi, Zhou Qinhua, Ying Wenjing, Hui Xiaoying, Sun Bijun, Hou Jia, Qian Feng, Wang Xiaochuan, Sun Jinqiao

Abstract excerpt

PURPOSE: Autoimmunity is a significant feature of APDS1 patients. We aimed to explore the pathogenic immune phenotype and possible mechanisms of autoimmunity in APDS1 patients. METHODS: The clinical records and laboratory data of 42 APDS1 patients were reviewed. Immunophenotypes were evaluated by multiparametric flow cytometry. Autoantibodies were detected via antigen microarray analysis. RESULTS: A total of 42...

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Identifiers

PMID: 38634985
DOI: 10.1007/s10875-024-01705-w
PMCID: PMC11026262

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