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Hyperactivation of the PI3K pathway in inborn errors of immunity: current understanding and therapeutic perspectives

1 Jan 2024

Abstract excerpt

Abstract The phosphoinositide-3-kinase (PI3K) pathway function is crucial to the normal development, differentiation, and function of immune cells including B, T, and NK cells. Following the description of two cohorts of patients with an inboirn error of immunity (also known as primary immunodeficiency) with gain-of-function variants in the PIK3CD gene a decade ago, the disease entity activated PI3K delta...

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PMID: 39679264
DOI: 10.1093/immadv/ltae009

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