Article
Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling
2025-12-27
Abstract excerpt
Ovarian cancer incidence and mortality increase with age, yet how aging shapes tumor progression and the immune microenvironment remains poorly defined. Using orthotopic syngeneic models of distinct cellular origins (ovarian surface epithelial and fallopian tube-derived) in young versus aged mice, we show that aged hosts exhibit higher tumor burden, metastasis and ascites. Follicle depletion in young mice did not...
Topics
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- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Genetics, Aging, and Longevity in Model Organisms
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Single-cell and spatial transcriptomics
Identifiers and source
- Literature Corpus work
- 9831547e-cfaf-5acb-9ef7-a4c32c1e607a
- DOI
- 10.64898/2025.12.23.695206