Article

Breast cancer metabolism and responsiveness to dichloroacetate: relationships with <sup>15</sup> N and <sup>13</sup> C natural abundance

2026-03-09

Abstract excerpt

<h4>Background</h4> Metabolic reprogramming is a hallmark of breast cancer (BrCa), with alterations in glycolysis, glutamine metabolism, and the urea cycle contributing to tumour progression. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, shifts metabolism toward oxidative phosphorylation and has been proposed as a therapeutic agent. While isotope tracing is well-established, natural isot...

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Literature Corpus work: 9824dac7-defe-5dc5-94e6-9ee67e989f1c
DOI: 10.64898/2026.03.09.710495

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