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Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

22 Aug 2023

Abstract excerpt

Stable isotopes are powerful tools to assess metabolism. 13C labeling is detected using nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS). MS has excellent sensitivity but generally cannot discriminate among different 13C positions (isotopomers), whereas NMR is less sensitive but reports some isotopomers. Here, we develop an MS method that reports all 16 aspartate and 32 glutamate...

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PMID: 37611583
DOI: 10.1016/j.cmet.2023.07.013

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