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Multi‐omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics

28 Nov 2025

Abstract excerpt

Epithelioid sarcoma (EpS) is an aggressive soft tissue sarcoma characterized by switch/sucrose non-fermentable (SWI/SNF)-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) loss [1]. Conventionally, EpS is histologically classified as either distal or proximal subtype, each exhibiting distinct clinical behaviors; these sometimes co-exist as “hybrid” EpS [2, 3]....

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PMID: 41313621
DOI: 10.1002/cac2.70077

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