Article

Preclinical Evaluation of PTK7-Targeted Radionuclide Therapy

2024-11-19

Abstract excerpt

Protein tyrosine kinase 7 (PTK7), a receptor found in tumor-initiating cells, is expressed in various malignancies, including ovarian cancer. While PTK7 has been explored as a target for antibody-drug conjugates, this study is the first to investigate its potential for targeted radionuclide therapy. We developed a murine monoclonal IgG1 antibody (mOI-1) using hybridoma technology and generated a chimeric version (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 981235a8-662c-58c3-af2c-ed114ad2d984
DOI: 10.1101/2024.11.18.624082

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Preclinical Evaluation of PTK7-Targeted Radionuclide TherapyDOI 10.1101/2024.11.18.624082Read

Therapeutic targeting of the protein tyrosine kinase-7 in cancer: an overviewSemantic proximity Read

Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis.Semantic proximity Read

Targeting the TRA-1-60 Glycoepitope Enables Selective ImmunoPET Imaging of Ovarian CancerSemantic proximity Read

Development of an Engineered Single-Domain Antibody for Targeting MET in Non-Small Cell Lung CancerSemantic proximity Read

P7 antigen expression in human breast cancer.Semantic proximity Read

scFv-Fcs as a Radiotheranostic Platform for Targeting TRA-1-60 in Pancreatic CancersSemantic proximity Read

Theragnostic imaging using radiolabeled antibodies and tyrosine kinase inhibitors.Semantic proximity Read

ITC-6102RO, A Novel B7-H3 Antibody-Drug Conjugate, Exhibits Potent Therapeutic Effects against B7-H3 Expressing Solid TumorsSemantic proximity Read

A general approach to reduce off-target radioactivity in vivo via Tetrazine-Knock-Out (TKO)Semantic proximity Read

Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies.Semantic proximity Read

Targeting Triple Negative Breast Cancer with a Nucleus-Directed p53 Tetramerization Domain Peptide.Semantic proximity Read

Targeted therapy of breast cancer using PLAC1 antibody-drug conjugateSemantic proximity Read