Article
Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2007
Knogler Karin, Grünberg Jürgen, Zimmermann Kurt, Cohrs Susan, Honer Michael, Ametamey Simon, Altevogt Peter, Fogel Mina, Schubiger P August, Novak-Hofer Ilse
Abstract excerpt
PURPOSE: We examined the tumor-targeting and therapeutic effects of (67)Cu-labeled single amino acid mutant forms of anti-L1 monoclonal antibody chCE7 in nude mice with orthotopically implanted SKOV3ip human ovarian carcinoma cells. EXPERIMENTAL DESIGN: For radioimmunotherapy, chCE7 antibodies with a mutation of histidine 310 to alanine (chCE7H310A) and a mutation of asparagine 297 to glutamine (chCE7agl) were...
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