Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic targeting of the protein tyrosine kinase-7 in cancer: an overview

28 Oct 2024

Abstract excerpt

The protein tyrosine kinase-7 (PTK7) is an evolutionarily conserved transmembrane receptor that has emerged as a potential therapeutic target for human tumors. PTK7 is a pseudokinase that is involved in the modulation of the Wnt signaling pathway through interactions with other receptors. These interactions result in targeted gene activation that regulates cell polarity, migration, and proliferation during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Research and Treatments
Share to CAR-T cell therapy research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39468753
DOI: 10.1093/oncolo/oyae290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic targeting of the protein tyrosine kinase-7 in cancer: an overviewPMID 39468753Read ↗

Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancerSemantic proximity Read ↗

Discovery of small molecule inhibitors of the PTK7/β-catenin inter-action targeting the Wnt signaling pathway in colorectal cancerSemantic proximity Read ↗

Receptor tyrosine kinases: biological functions and anticancer targeted therapySemantic proximity Read ↗

Preclinical Evaluation of PTK7-Targeted Radionuclide TherapySemantic proximity Read ↗

Chimeric antigen receptor T cell-based targeting of CD317 as a novel immunotherapeutic strategy against glioblastomaSemantic proximity Read ↗

Kinase-targeted cancer therapies: progress, challenges and future directionsSemantic proximity Read ↗

New B7 Family Checkpoints in Human CancersSemantic proximity Read ↗

PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells.Semantic proximity Read ↗

Grb7-based molecular therapeutics in cancerSemantic proximity Read ↗

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.Semantic proximity Read ↗

Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway.Semantic proximity Read ↗

Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic TargetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.