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Article

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.

Nature medicine - 1 Sept 2004

Petrova Tatiana V, Karpanen Terhi, Norrmén Camilla, Mellor Russell, Tamakoshi Tomoki, Finegold David, Ferrell Robert, Kerjaschki Dontscho, Mortimer Peter, Ylä-Herttuala Seppo, Miura Naoyuki, Alitalo Kari

Abstract excerpt

Lymphatic vessels are essential for the removal of interstitial fluid and prevention of tissue edema. Lymphatic capillaries lack associated mural cells, and collecting lymphatic vessels have valves, which prevent lymph backflow. In lymphedema-distichiasis (LD), lymphatic vessel function fails because of mutations affecting the forkhead transcription factor FOXC2. We report that Foxc2(-/-) mice show abnormal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15322537
DOI: 10.1038/nm1094

Genes

FOXC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.PMID 15322537Read ↗

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