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Article

Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting.

Nature genetics - 1 Apr 2009

Hogan Benjamin M, Bos Frank L, Bussmann Jeroen, Witte Merlijn, Chi Neil C, Duckers Henricus J, Schulte-Merker Stefan

Abstract excerpt

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19287381
DOI: 10.1038/ng.321

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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