Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function

5 Apr 2016

Abstract excerpt

The molecular mechanisms underlying lymphatic vascular development and function are not well understood. Recent studies have suggested a role for endothelial cell (EC) mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) in developmental angiogenesis and atherosclerosis. Here, we show that constitutive loss of EC Map4k4 in mice causes postnatal lethality due to chylothorax, suggesting that Map4k4 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphatic Disorders and Treatments
Share to Lymphatic System and Diseases
Share to Sympathectomy and Hyperhidrosis Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27044870
DOI: 10.1128/mcb.01121-15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and FunctionPMID 27044870Read ↗

H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in miceSemantic proximity Read ↗

Developmental and pathological lymphangiogenesis: from models to human diseaseSemantic proximity Read ↗

Lymphatic vascular morphogenesis in development, physiology, and diseaseSemantic proximity Read ↗

Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivationSemantic proximity Read ↗

Development of the lymphatic vascular system: A mystery unravelsSemantic proximity Read ↗

Lymphatic Vasculature DevelopmentSemantic proximity Read ↗

Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for TherapySemantic proximity Read ↗

VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vesselsSemantic proximity Read ↗

THE LYMPHATIC VASCULATURE: Recent Progress and ParadigmsSemantic proximity Read ↗

Endothelial ERK signaling controls lymphatic fate specificationSemantic proximity Read ↗

When form meets function: the cells and signals that shape the lymphatic vasculature during developmentSemantic proximity Read ↗

Genetics of lymphatic anomalies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.