Article

Loss of cBAF Complex Confers Sorafenib Resistance in Liver Cancer

2026-06-12

Abstract excerpt

Sorafenib resistance limits the clinical benefit of first-line therapy in hepatocellular carcinoma (HCC), yet the epigenetic mechanisms underlying this resistance remain poorly understood. Using a chromatin-focused CRISPR/Cas9 dropout screen in HepG2 cells, we identified subunits of the canonical BAF (cBAF) complex — ARID1A, ARID1B, and SMARCC1 — as functional drivers of sorafenib resistance, while loss of the PBA...

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Literature Corpus work: 97e9767d-049c-55b9-a387-56fbc119be03
DOI: 10.64898/2026.06.11.731725

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