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Targeting PCBP1 Sequentially Represses BAG1 and SOX2/β-catenin Axis to Inhibit HCC Cells Proliferation and Reverse Intrinsic Sorafenib Resistance

2026-08-12

Abstract excerpt

<title>Abstract</title> <p>Background: Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related mortality, and sorafenib remains the first-line systemic therapy for advanced HCC. Nevertheless, up to 70% of patients exhibit intrinsic sorafenib resistance with unclear molecular mechanisms. <h4>Methods:</h4> In vitro cellular phenotypes including sorafenib sensitivity, proliferation, migrati...

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Literature Corpus work
25a05135-a19c-5d76-a36d-18f92abe498a
DOI
10.21203/rs.3.rs-10654693/v1
Open publication

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Targeting PCBP1 Sequentially Represses BAG1 and SOX2/β-catenin Axis to Inhibit HCC Cells Proliferation and Reverse Intrinsic Sorafenib ResistanceDOI 10.21203/rs.3.rs-10654693/v1
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