Article

Combining functional annotation and multi-trait fine-mapping methods improves fine-mapping resolution at glycaemic trait loci

2024-11-15

Abstract excerpt

The Meta-Analysis of Glucose and Insulin-related traits Consortium (MAGIC) identified 242 loci associated with glycaemic traits fasting insulin (FI), fasting glucose (FG), 2h-Glucose (2hGlu), and glycated haemoglobin (HbA1c). However, for the majority, the causal variant(s) remain(s) unknown. Modelling multiple traits and integrating functional annotations have each been shown to improve fine-mapping resolution. H...

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Literature Corpus work: 97e7bab5-1eba-55ef-b167-a01bdadce939
DOI: 10.1101/2024.11.13.623384

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