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Article

Development of Metabolic Synthetic Lethality and Its Implications for Thyroid Cancer.

Endocrinology and metabolism (Seoul, Korea) - 1 Feb 2022

Ju Sang-Hyeon, Lee Seong Eun, Kang Yea Eun, Shong Minho

Abstract excerpt

Cancer therapies targeting genetic alterations are a topic of great interest in the field of thyroid cancer, which frequently harbors mutations in the RAS, RAF, and RET genes. Unfortunately, U.S. Food and Drug Administration-approved BRAF inhibitors have relatively low therapeutic efficacy against BRAF-mutant thyroid cancer; in addition, the cancer often acquires drug resistance, which prevents effective...

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Identifiers

PMID: 35255601
DOI: 10.3803/EnM.2022.1402
PMCID: PMC8901971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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