Article

B Cell Tolerance and BCR Signaling Dysregulation in NF155-Mediated Autoimmune Nodopathies

2025-08-12

Abstract excerpt

<h4>Objective</h4> Autoimmune nodopathies (AINs) are a group of rare, acquired autoimmune neuropathies with distinct clinical features and the presence of circulating autoantibodies - often of the immunoglobulin G4 (IgG4) subclass - targeting proteins at the node of Ranvier. Defects in B cell tolerance checkpoints have been implicated in several autoimmune diseases. Prior work identified defective B cell toleranc...

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Literature Corpus work: 97d4a663-7c0a-5844-be78-184a5ce76e27
DOI: 10.1101/2025.08.10.669569

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