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Systematic variant-to-gene mapping highlights <i>TGFB2</i> and <i>VEGFA</i> as adipokine-coding genes with non-obese, insulin-resistance-like characteristics and distinct disease risks

2026-05-04

Abstract excerpt

Adipokines are key metabolic hormones that modulate cardiometabolic risk through multiple distinct biological pathways. To delineate these pathways, we systematically mapped adipokine⍰associated variants to putative effector genes (V2G) across□1,669 human traits in three ancestries from the Million Veteran Program. Grouping the variants by their associations with insulin⍰resistance-related traits yielded six discr...

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Identifiers and source

Literature Corpus work
97c51c44-7c12-5d2a-b2bc-06a78535efa3
DOI
10.64898/2026.05.01.26352257
Open publication

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Systematic variant-to-gene mapping highlights <i>TGFB2</i> and <i>VEGFA</i> as adipokine-coding genes with non-obese, insulin-resistance-like characteristics and distinct disease risksDOI 10.64898/2026.05.01.26352257
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