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Article

Genetic Evidence for Distinct Biological Mechanisms That Link Adiposity to Type 2 Diabetes: Toward Precision Medicine.

Diabetes - 1 Jun 2024

Abraham Angela, Cule Madeleine, Thanaj Marjola, Basty Nicolas, Hashemloo M Amin, Sorokin Elena P, Whitcher Brandon, Burgess Stephen, Bell Jimmy D, Sattar Naveed, Thomas E Louise, Yaghootkar Hanieh

Abstract excerpt

We aimed to unravel the mechanisms connecting adiposity to type 2 diabetes. We used MR-Clust to cluster independent genetic variants associated with body fat percentage (388 variants) and BMI (540 variants) based on their impact on type 2 diabetes. We identified five clusters of adiposity-increasing alleles associated with higher type 2 diabetes risk (unfavorable adiposity) and three clusters associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Type 2

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Identifiers

PMID: 38530928
DOI: 10.2337/db23-1005
PMCID: PMC11109787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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