Article

RIPK4 driven by TP53 mutations promotes resistance to redox stress of CRC by phosphorylating MTHFD1

2024-08-06

Abstract excerpt

This study investigates advanced colorectal cancer (CRC), focusing on its tendency for distant metastasis and chemotherapy resistance. It highlights the importance of PANoptosis, a cell death pathway, and the role of the Receptor-interacting serine/threonine-protein kinase (RIPK) family in tumor progression. RIPK4’s tissue-specific functions in cancer cell behavior are emphasized, including its influence on invasi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97c25413-ad12-561c-a52e-b4c564bf149e
DOI: 10.1101/2024.08.06.606759

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RIPK4 driven by TP53 mutations promotes resistance to redox stress of CRC by phosphorylating MTHFD1DOI 10.1101/2024.08.06.606759Read

Cellular and molecular events in colorectal cancer: biological mechanisms, cell death pathways, drug resistance and signalling network interactionsSemantic proximity Read

Mitochondria: a crucial factor in the progression and drug resistance of colorectal cancerSemantic proximity Read

APOA5 alleviates reactive oxygen species to promote oxaliplatin resistance in PIK3CA-mutated colorectal cancer.Semantic proximity Read

Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: A reviewSemantic proximity Read

FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1Semantic proximity Read

miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPESemantic proximity Read

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targetsSemantic proximity Read

Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinomaSemantic proximity Read

The interplay between driver mutation and oxidative stress in colorectal cancer: from pathogenesis to therapeutics.Semantic proximity Read

Stress-Survival Pathway Profiling Reveals MCM10 as a Candidate Biomarker of Hispanic Colorectal Cancer DisparitiesSemantic proximity Read

Defective autophagy control by the p53 rheostat in cancerSemantic proximity Read

LRP8 Promotes Colorectal Cancer Progression by Suppressing Ferroptosis through the SLC3A2/GPX4 Signalling Axis LRP8/SLC3A2/GPX4 promoting CRCSemantic proximity Read