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Article

Defective autophagy control by the p53 rheostat in cancer

15 Jan 2010

Abstract excerpt

Autophagy is a finely regulated, lysosomal catabolic pathway that contributes to the turnover of long-lived proteins and to the elimination of old/damaged organelles. Autophagy exerts bona fide oncosuppressive functions by: (1) limiting chromosomal instability; (2) reducing potentially mutagenic oxidative stress; and (3) restraining intratumoral necrosis and local inflammation. Defective autophagy constitutes a...

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PMID: 20023384
DOI: 10.4161/cc.9.2.10493

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