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New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

23 Feb 2017

Abstract excerpt

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still remains a major life-threatening malignancy. CRC etiology entails both genetic and environmental factors. Macroautophagy/autophagy and the unfolded protein response (UPR) are fundamental mechanisms involved in the regulation of cellular responses to environmental and genetic stresses. Both pathways are interconnected and regulate...

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PMID: 28358273
DOI: 10.1080/15548627.2017.1290751

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