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Article

APOA5 alleviates reactive oxygen species to promote oxaliplatin resistance in PIK3CA-mutated colorectal cancer.

Aging - 6 Jun 2024

Liu Yu-Lin, Xiang Zhuo, Zhang Bo-Ya, Zou Yu-Wei, Chen Gui-Lai, Yin Li, Shi Yan-Long, Xu Li-Li, Bi Jingwang, Wang Qiang

This publication is marked as retracted by the source.

Abstract excerpt

Although platinum-based chemotherapy is the frontline regimen for colorectal cancer (CRC), drug resistance remains a major challenge affecting its therapeutic efficiency. However, there is limited research on the correlation between chemotherapy resistance and lipid metabolism, including PIK3CA mutant tumors. In this present study, we found that PIK3CA-E545K mutation attenuated cell apoptosis and increased the...

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
Drug Resistance, Neoplasm
Apolipoprotein A-V
Oxaliplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reactive Oxygen Species

Class I Phosphatidylinositol 3-Kinases

Mutation

Animals

Cell Line, Tumor

Antineoplastic Agents

Mice

Male

Apoptosis

Sterol Regulatory Element Binding Protein 1

Female

Gene Expression Regulation, Neoplastic

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 38848145
DOI: 10.18632/aging.205872
PMCID: PMC11210231

Genes

APOA5
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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