Article

Targeted Bayesian Prioritization Identifies Glutamatergic and Synaptic Plasticity Pathways as Key Contributors to Borderline Personality Disorder Risk

2025-12-29

Abstract excerpt

<h4>Background: </h4> Borderline personality disorder (BPD) combines pronounced affective lability with impulsive behaviour. Magnetic-resonance spectroscopy, post-mortem work and pilot pharmacological studies all point to abnormalities in glutamatergic transmission and synaptic plasticity. A recent genome-wide association study (GWAS) of European ancestry that excluded cases with bipolar disorder or schizophrenia...

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Literature Corpus work: 97a5fdbf-2e10-5b84-9276-b55844e062f9
DOI: 10.20944/preprints202512.2482.v1

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