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Article

Investigation of genetic loci shared between bipolar disorder and risk-taking propensity: potential implications for pharmacological interventions.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2021

Pisanu Claudia, Congiu Donatella, Severino Giovanni, Ardau Raffaella, Chillotti Caterina, Del Zompo Maria, Baune Bernhard T, Squassina Alessio

Abstract excerpt

Patients with bipolar disorder (BD) often show increased risk-taking propensity, which may contribute to poor clinical outcome. While these two phenotypes are genetically correlated, there is scarce knowledge on the shared genetic determinants. Using GWAS datasets on BD (41,917 BD cases and 371,549 controls) and risk-taking (n = 466,571), we dissected shared genetic determinants using conjunctional false...

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Share to Bipolar Disorder
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Risk-Taking

Source

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Identifiers

PMID: 34035470
DOI: 10.1038/s41386-021-01045-y
PMCID: PMC8280111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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