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Article

Identifying drug targets for schizophrenia through gene prioritization.

Translational psychiatry - 4 Feb 2026

Kraft Julia, Braun Alice, Awasthi Swapnil, Panagiotaropoulou Georgia, Schipper Marijn, Bell Nathaniel, Posthuma Danielle, Pardiñas Antonio F, Ripke Stephan, Heilbron Karl

Abstract excerpt

Schizophrenia genome-wide association studies (GWASes) have identified >250 significant loci and prioritized >100 disease-related genes. However, gene prioritization efforts have mostly been restricted to locus-based methods that ignore information from the rest of the genome. To more accurately characterize genes involved in schizophrenia etiology, we applied a combination of highly-predictive tools to a...

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Identifiers

PMID: 41639063
DOI: 10.1038/s41398-026-03813-0
PMCID: PMC12923709

Genes

AKT3
CACNA1C
DRD2
GABBR2
GRIN2A
GRM1
PDE4B
VRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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