Article
Recent advances in our understanding of neurodegeneration.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2009
Jellinger Kurt A
Abstract excerpt
Neurodegenerative diseases are featured by progressive dysfunction and death of cells in selected areas in the nervous system, determining clinical presentation. Neuronal loss is associated with conformational changes in proteins that result in extra- and intra-cellular accumulation of misfolded proteins, representing the hallmarks of many neurodegenerative disorders, summarized as proteinopathies. Intermediate...
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