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Article

Tau proteotasis in Alzheimer's disease.

Advances in protein chemistry and structural biology - 1 Jan 2025

Chinnathambi Subashchandrabose

Abstract excerpt

Tau protein accumulation is one of the characteristic features of Alzheimer's disease (AD). Their accumulation is driven by the formation of intermediate toxic oligomers of Tau to the highly ordered neurofibrillary tangles. Cellular machineries engage different types of proteins such as, chaperone-co-chaperones complex, ubiquitin, kinases, proteases etc., to clear the aberrantly accumulated Tau protein which...

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PMID: 40973404
DOI: 10.1016/bs.apcsb.2024.09.003

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