Article
Inflammatory bowel disease and primary sclerosing cholangitis: immunological links and clinical outlook.
Expert review of clinical immunology - 1 Apr 2026
Massironi Sara, Fanizzi Fabrizio, Invernizzi Federica, Furfaro Federica, Ciocca Lorenzo, Arcari Ivan, Allocca Mariangela, Peyrin-Biroulet Laurent, Danese Silvio
Abstract excerpt
INTRODUCTION: Primary sclerosing cholangitis (PSC) represents a progressive fibroinflammatory cholangiopathy intricately linked to inflammatory bowel disease (IBD), forming a distinctive overlap syndrome driven by immune dysregulation and gut-liver axis disruption and characterized by a markedly increased risk of colorectal and hepatobiliary cancers. AREAS COVERED: This review summarizes current understanding of...
Topics
- Humans
- Cholangitis, Sclerosing
- Inflammatory Bowel Diseases
- Animals
- Gastrointestinal Microbiome
- Colorectal Neoplasms
- Genetic Predisposition to Disease
- Liver Neoplasms