Article
The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis.
Cancer discovery - 1 Mar 2021
Hong Xin, Roh Whijae, Sullivan Ryan J, Wong Keith H K, Wittner Ben S, Guo Hongshan, Dubash Taronish D, Sade-Feldman Moshe, Wesley Benjamin, Horwitz Elad, Boland Genevieve M, Marvin Dieuwke L, Bonesteel Todd, Lu Chenyue, Aguet François, Burr Risa, Freeman Samuel S, Parida Laxmi, Calhoun Katherine, Jewett Michelle K, Nieman Linda T, Hacohen Nir, Näär Anders M, Ting David T, Toner Mehmet, Stott Shannon L, Getz Gad, Maheswaran Shyamala, Haber Daniel A
Abstract excerpt
Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from patients with melanoma coordinately upregulate lipogenesis and iron homeostasis pathways. These are correlated with both intrinsic and acquired resistance to BRAF inhibitors across clonal cultures of BRAF-mutant CTCs. The lipogenesis...
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