Article

Effects of Human Sex Chromosome Dosage on Spatial Chromosome Organization

2018-06-13

Abstract excerpt

Sex chromosome aneuploidies (SCAs) are common genetic syndromes characterized by the presence of an aberrant number of X and Y chromosomes due to meiotic defects. These conditions impact structure and function of diverse tissues, but the proximal effects of SCA on genome organization are unknown. Here, to determine the consequences of SCAs on global genome organization, we have analyzed multiple architectural feat...

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Literature Corpus work: 974a80d4-f6e2-5990-b46e-e96288ad726d
DOI: 10.1101/346742

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