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Chromosome architecture in the decondensing human sperm nucleus

22 Sept 2005

Abstract excerpt

Whereas recent studies demonstrated a well-defined nuclear architecture in human sperm nuclei, little is known about the mode of DNA compaction above the elementary structural unit of nucleoprotamine toroids. Here, using fluorescence in-situ hybridization (FISH) with arm-specific DNA probes of chromosomes 1, 2 and 5, we visualized arm domains and established hierarchical levels of sperm chromatin structures. The...

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Share to Chromosomal and Genetic Variations
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PMID: 16179611
DOI: 10.1242/jcs.02581

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