Article

Dicentric chromosome breakage in <i>Drosophila melanogaster</i> is influenced by pericentric heterochromatin and reveals a novel class of fragile site

2022-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Chromosome breakage plays an important role in the evolution of karyotypes, and can produce deleterious effects within a single individual, such as aneuploidy or cancer. Forces that influence how and where chromosomes break are not well understood. In humans, breakage tends to occur in conserved hotspots called common fragile sites (CFS), especially during replication stress. By following the fa...

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Literature Corpus work: 973bb48e-1576-5809-9b2c-46bb36874b89
DOI: 10.1101/2022.10.13.512123

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