Article

Clone-level multi-modal prediction of tumour drug response

2026-05-11

Abstract excerpt

Tumour heterogeneity presents a major challenge for precision oncology, as genetically and phenotypically distinct tumour clones may respond differently to therapy. To address this, we introduce scClone2DR, a probabilistic multi-modal framework that predicts drug responses at the level of individual tumour clones by integrating single-cell DNA and RNA sequencing with ex-vivo drug-screening data. In simulations, sc...

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Literature Corpus work: 5d246fbb-d8a8-52fd-973a-6435fd678759
DOI: 10.64898/2026.05.06.723206

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