Personalized cancer treatment strategies incorporating irreversible and reversible drug resistance mechanisms

Abstract excerpt

<h4>ABSTRACT</h4> Despite advances in targeted cancer therapy, the promise of precision medicine has been limited by resistance to these treatments. In this study, we propose a mathematical modelling framework incorporating cellular heterogeneity, genetic evolutionary dynamics, and non-genetic plasticity, accounting for both irreversible and reversible drug resistance. Previously we proposed Dynamic Precision Med...

Topics

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• Antineoplastic Combined Chemotherapy Protocols
• Cancer Genomics and Diagnostics
• Drug Resistance, Neoplasm
• Immunotherapy
• Models, Biological
• Models, Theoretical
• Neoplasms
• Phenotype

Identifiers and source

Literature Corpus work

2cd42268-f833-5c76-b0ee-36cb1ea2d344

DOI

10.1101/2024.11.03.621749